WASHINGTON (AP) — Rep. Mo Brooks says the "failure" of the GOP health care overhaul is ultimately Senate Majority Leader Mitch McConnell's responsibility.

The Alabama Republican said Friday on CNN that McConnell should press the Senate to pass a rewrite of President Barack Obama's signature law — or step aside.

Brooks said, "If they're going to quit, well then, maybe by God they ought to start at the top with Mitch McConnell leaving his position."

He added that "The leadership at the top is responsible. The buck stops there."

Brooks also questioned whether McConnell can accomplish Trump's other priorities, such as tax and infrastructure reform. The defeat early Thursday morning of the health care bill, Brooks said, is potentially "a killer" for the rest of the Trump agenda.

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5:40 a.m.

House Minority Leader Nancy Pelosi has taken comfort in the defeat in the Senate of a Republican-pushed measure aimed at scaling back, or partially repealing, former President Back Obama's Affordable Care Act.

In a statement following defeat of the measure on a 49-51 vote, the California Democrat says, "The American people have spoken loud and clear against the higher costs and monstrous cruelty of Trumpcare."

She adds, "Now, Congress must finally pivot to the long overdue bipartisan work to update and improve the Affordable Care Act and to continue to lower Americans' health costs." Her counterpart in the Senate, Chuck Schumer of New York, said after the votes that Democrats who resisted the GOP legislation "are not celebrating." But he also said that he's "relieved" the measure didn't pass.

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3:39 a.m.

Dealing a serious blow to President Donald Trump's agenda, the Senate early Friday rejected a measure to repeal parts of former President Barack Obama's health care law after a night of high suspense in the U.S. Capitol.

Unable to pass even a so-called "skinny repeal," it was unclear if Senate Republicans could advance any health bill despite seven years of promises to repeal "Obamacare."

"This is clearly a disappointing moment," said Senate Majority Leader Mitch McConnell, R-Ky. "I regret that our efforts were not enough, this time."

"It's time to move on," he said. The vote was 49-51 with three Republicans joining all Democrats in voting 'no.'

McConnell put the health bill on hold and announced that the Senate would move onto other legislation next week.

Trump responded on Twitter: "3 Republicans and 48 Democrats let the American people down. As I said from the beginning, let ObamaCare implode, then deal. Watch!"