NEW YORK (AP) — U.S. stock indexes gave up an early gain and ended slightly lower following a mixed set of profit reports from giants like Google's parent company and Eli Lilly.

The S&P 500 slipped 0.3% Wednesday. The Dow Jones Industrial Average fell 0.2%, and the Nasdaq composite fell 0.6% from its record set the day before.

Alphabet rallied after becoming the latest "Magnificent Seven" stock to deliver strong profit.

Eli Lilly sank on concerns about two of its blockbuster drugs, while chip stocks fell following Advanced Micro Devices' latest profit report.

Treasury yields rose in the bond market.