WASHINGTON (AP) — With a burst of executive orders, President Joe Biden served notice Thursday that America's war on COVID-19 is under new command, promising an anxious nation progress to reduce infections and lift the siege it has endured for nearly a year.

At the same time, he tried to manage expectations in his second day in office, saying despite the best intentions "we're going to face setbacks." He brushed off a reporter's question on whether his goal of 100 million coronavirus shots in 100 days should be more ambitious, a point pressed by some public health experts.

The 10 orders signed by Biden are aimed at jump starting his  national COVID-19 strategy to increase vaccinations and testing, lay the groundwork for reopening schools and businesses, and immediately increase the use of masks — including a requirement that Americans mask up for travel. One directive calls for addressing health care inequities in minority communities hard hit by the virus.

"We didn't get into this mess overnight, and it will take months to turn this around," Biden said at the White House. U.S. deaths have have surged past 400,000, and he noted projections that they could reach 500,000 in a month.

But then, looking directly into the TV camera, Biden declared: "To a nation waiting for action, let me be clear on this point: Help is on the way."

The new president has vowed to take far more aggressive measures to contain the virus than his predecessor, starting with stringent adherence to public health guidance. A key difference is that under Biden, the federal government is assuming full responsibility for the COVID response. And instead of delegating major tasks to states, he is offering to help them with technical backup and federal money.

He faces steep obstacles, with the virus actively spreading in most states, slow progress on the vaccine rollout and political uncertainty over whether congressional Republicans will help him pass a  $1.9 trillion economic relief and COVID response package.

On Thursday a group influential with Republican office holders lent its support to Biden's strategy. The U.S. Chamber of Commerce said, "We support the new administration's focus on removing roadblocks to vaccinations and reopening schools, both of which are important steps to accelerating a broad-based economic recovery for all Americans."

Biden officials have said they've been hampered by a lack of cooperation from the Trump administration during the transition. They say they don't have a complete understanding of their predecessors' actions on vaccine distribution. And they face a litany of complaints from states that say they are not getting enough vaccine even as they are being asked to vaccinate more categories of people.

The U.S. mask order for travel implemented by Biden applies to airports and planes, ships, intercity buses, trains and public transportation. Travelers from abroad must furnish a negative COVID-19 test before departing for the U.S. and must quarantine upon arrival. Biden has already mandated masks on federal property.

Although airlines, Amtrak and other transport providers now require masks, Biden's order makes it a federal mandate, leaving little wiggle room for passengers tempted to argue about their rights. It marks a sharp break with the culture of President Donald Trump's administration, under which masks were optional, and Trump made a point of going maskless and hosting big gatherings of like-minded supporters. Science has shown that masks, properly worn, cut down on coronavirus transmission.

Biden is seeking to expand testing and vaccine availability, with the goal of 100 million shots in his first 100 days in office. But some independent experts say his administration should strive for two or three times that number. Even with the slow pace of vaccinations, the U.S. is already closing in on 1 million shots a day.

"It's a disappointingly low bar," said Dr. Leana Wen, a public health expert and emergency physician.

Asked about that at the White House on Thursday, Biden told a reporter: "When I announced it, you all said it's not possible. Come on, give me a break, man."

The Democratic president has directed the Federal Emergency Management Agency to begin setting up vaccination centers, aiming to have 100 up and running in a month. He's ordering the Centers for Disease Control and Prevention to begin a program to make vaccines available through local pharmacies starting next month, building on a plan devised by the Trump administration. And he's launching an effort to train more people to administer shots.

Biden has set a goal of having most K-8 schools reopen in his first 100 days, and he's ordering the departments of Education and Health and Human Services to provide clear guidance for reopening them safely. States would also be able to tap FEMA's Disaster Relief Fund to help get schools back open.

Getting schools and child care going will help ease the drag on the U.S. economy, making it easier for parents to return to their jobs and for restaurants to find lunch-time customers.

But administration officials stressed that reopening schools safely depends on increased testing.

Biden is giving government agencies a green light to use the Cold War-era Defense Production Act to direct manufacturing. It allows the government to direct private industry to produce supplies needed in times of national emergency. In this case it could be anything from swabs, to masks, to certain chemicals.

 "We do not have nearly enough testing capacity in this country," said White House coronavirus coordinator Jeff Zients. "We need (more) money in order to really ramp up testing, which is so important to reopen schools and businesses."

This means that efforts to boost the economy could hinge on how quickly lawmakers act on the $1.9 trillion package proposed by Biden, which includes separate planks such as $1,400 in direct payments to most working people, a $15 minimum wage and aid to state and local governments that some Republican lawmakers see as unnecessary for addressing the public health emergency.

The Biden plan estimates that a national vaccination strategy with expanded testing requires $160 billion, and he wants an additional $170 billion to aid the reopening of schools and universities. The proposal also calls for major investment in scientific research to track new variants of the virus.

As part of his strategy, Biden ordered establishment of a Health Equity Task Force to ensure that minority and underserved communities are not left out of the government's response. Blacks, Latinos and Native Americans have borne a heavy burden of death and disease from the virus. Surveys have shown vaccine hesitancy is high among African Americans, a problem the administration plans to address through an education campaign.

But Dr. Marcella Nunez-Smith, the top White House health adviser on minority communities, said she's not convinced that race is a factor in vaccination reluctance. Disparities seem to have more to do with risky jobs and other life circumstances.

"It's not inherent to race," she said. "It's from the exposures."

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Associated Press writers Collin Binkley and Josh Boak contributed to this report.