Stocks closed modestly lower on Wall Street Wednesday, handing the market its second straight loss.

Banks and technology companies accounted for much of the slide as investors shifted money into U.S. bonds, precious metals and other holdings considered safe havens after more than a week of aggressive buying.

Energy stocks took the heaviest losses following a 4% drop in the price of U.S. crude oil. That helped outweigh gains in health care, utilities and elsewhere in the market.

The latest decline followed a broad drop in stocks that ended a five-day winning streak for the market. The Federal Reserve set off last week's rally when it signaled that it is willing to cut interest rates to help stabilize the economy if the U.S. trade war with China starts to crimp growth.

Investors are worried that the dispute will drag on much longer than previously expected, weighing on economic growth and corporate profits. That has traders looking ahead to next week's Fed meeting.

"There are concerns about whether or not the Fed next week at its meeting is going to in fact continue to move its stance toward lowering rates," said Quincy Krosby, chief market strategist at Prudential Financial. "The increasing concern is that the global economy continues to slow and that the slowdown is affecting the United States as well."

The S&P 500 index lost 5.88 points, or 0.2%, to 2,879.84. The benchmark index rose 4.4% last week, its best weekly performance of 2019. It's now about 2.2% below its record set on April 30.

The Dow Jones Industrial Average fell 43.68 points, or 0.2%, to 26,004.83. The technology heavy Nasdaq composite index dropped 29.85 points, or 0.4%, to 7,792.72. The Russell 2000 index of smaller company stocks gained 0.68 points, or less than 0.1%, to 1,519.79.

Major indexes in Europe fell broadly.

The sell-off in U.S. markets reflects heightened investor uncertainty over trade and its impact on the economy.

President Donald Trump's decision to threaten an expansion of the trade war to Mexico made a jittery market even more uneasy. Those potential tariffs have been indefinitely postponed, but the move left its mark.

"This was a game changer, the idea that the administration would use tariffs to further policy that is not related to trade is concerning," said Kristina Hooper, chief global market strategist at Invesco.

Investors will likely have to deal with more volatility ahead of an economic summit later this month. Trump has said he plans to meet with Chinese President Xi Jinping at the Group of 20 summit in Osaka, Japan. But Trump has also said that if the two can't reach an agreement on trade, he'll proceed with tariffs on $300 billion goods from China that aren't already subject to import taxes.

Technology companies accounted for much of the market's slide Wednesday. The sector has been under the most pressure from swings in sentiment over the trade dispute between the U.S. and China. Cisco Systems fell 2.2% and Micron Technology dropped 5.4%.

Banks declined as bond prices rose, nudging yields lower. The yield on the 10-year Treasury note fell to 2.12% from 2.14% late Tuesday. Lower yields pull down interest rates on loans, reducing banks' profits. Bank Of America dropped 1% and Citigroup fell 1.6%.

Health care, utilities and industrial companies were among the gainers. Johnson & Johnson gained 1.4%, Exelon rose 2.5% and American Airlines Group added 1.7%.

Traders hammered shares in Dave & Buster's Entertainment after the company gave investors a dismal first quarter financial report and slashed its revenue forecast for the year. The stock plunged 22.4%, its worst one-day loss in over a year.

Mattel climbed 5.3% on published reports saying the toy maker rejected another buyout offer from Bratz doll maker MGE Entertainment.

Medidata Solutions slid 3.6% after the company announced a deal to be acquired at a discount price to French software company Dassault Systems. The deal values the provider of cloud-based services and software at $92.25 per share, less than its closing price of $94.75 on Tuesday.

In other trading, energy futures finished lower Wednesday. Benchmark U.S. crude slid 4% to settle at $51.14 a barrel. Brent crude oil, the international standard, dropped 3.7% to close at $59.97 a barrel.

Wholesale gasoline fell 4% to $1.69 per gallon. Heating oil slid 2.3% to $1.78 per gallon. Natural gas dipped 0.5% to $2.39 per 1,000 cubic feet.

Gold rose 0.4% to $1,336.80 per ounce, silver inched 0.1% higher to $14.75 per ounce and copper fell 0.7% to $2.65 per pound.

The dollar fell to 108.48 Japanese yen from 108.50 yen on Tuesday. The euro weakened to $1.1286 from $1.1332.